Endocrine Abstracts

Although the physico-chemical properties of colloid are not usually considered among the factors regulating thyroid function, it is conceivable that decreasing the viscosity of the intrafollicular colloid may facilitate diffusion of thyroglobulin (Tg) molecules within the lumina. The resulting increase in the number of contacts between Tg molecules and peroxidase at the apical membrane may promote the coupling reaction. Rats on a hormonal diet were given 0.5 μg T4</s...

It has been claimed that an increased level of thyroid autoantibodies in serum is associated with a higher risk for coronary heart disease (CHD). We explored whether this risk was mediated by subclinical hypothyroidism and hypercholesterolemia. We evaluated 945 consecutive hospital patients (mean age 59 years) according to strict electrocardiographic and clinical criteria for the presence of CHD. Serum cholesterol, LDL and HDL cholesterol and sensitive TSH were measured in all...

The effects of thyroid hormone deprivation and restitution on growth rate and pituitary and plasma GH levels have been studied in control and streptozotocin (STZ) – diabetic rats. GH was measured by a specific RIA using the NIAMOD rat-GH kit. Male Wistar rats which had been surgically thyroidectomized for 30 days and which had been stopped growing were injected i.p. with either saline or STZ (4 mg/100 g b.wt). Eight days after saline or STZ, groups of thyroidectomized con...

The purpose of this work was to investigate the effect of thyrotropin (TSH) on the thyroglobulin and on the polypeptides distribution in primary cultures of human thyroid cells.Thyroid cells isolated from cold nodules (follicular adenoma) were cultured for 5 to 8 days in the presence of 0.05 to 25 mU/ml of TSH (TSH cells) or in the absence of the hormone (control cells). After homogenization of the cells, thyroglobulin radioimmunoassay was performed. The...

Introduction: Nodular goiter is clinically recognizable restricted structure changes of the thyroid gland. FNA is the first line diagnostic test for an enlarged thyroid gland. TSH is known as a thyroid growth factor, but the pathogenic role of this hormone in thyroid oncogenesis is unclear.Objective: The aim of this study is to analyze the relationship between elevated serum TSH concentrations and thyroid malignancies in patients with nodular thyroid goi...

Introduction: Isolated IgA deficiency (SIgAD) is the most common form of primary immunodeficiency. Patients with SIgAD have an increased risk of both systemic and organ-specific autoimmune diseases. Autoimmune thyroid diseases (AITD) and type 1 diabetes mellitus (T1DM) are the most common autoimmune endocrine disorders. They occur frequently together, and this combination is nominated as autoimmune polyglandular syndrome type 3 (APS 3). Primary hyperparathyroidism (PHPT) is th...

Background: Ketoconazole is a synthetic antifungal drug, and powerful inhibitor of steroidogenesis. Oral ketoconazole blocks both ovarian and adrenal androgen biosynthesis, and glucocorticoid synthesis, leading to a reduction in circulating testosterone and cortisol levels. In subjects with an intact HPA axis, ketoconazole by decreasing cortisol levels leads to compensatory rise an ACTH level.Objectives: To assess influence ketoconasole induced changes i...

Background: Women with polycystic ovary syndrome (PCOS) appear at increased cardiovascular risk due in part to a dyslipidemia characterized by increased plasma triglyceride and reduced high density lipoprotein (HDL) cholesterol levels. Obesity, insulin resistance and hyperandrogenemia are features of PCOS and potentially affect lipid metabolism. On the other hand, obesity has an important influence on the lipid metabolism.Objectives: The aim of this stud...

In supine subjects aldosterone daily variations are determined by spontaneous PRA rhythmicity and ACTH secretory bursts. The aim of this study was to analyze diurnal and pulsatile aldosterone secretion in two patients with primary aldosteronism (PA): a 33-year-old woman with aldosterone producing adenoma (APA) and a 40-year-old woman with idiopathic adrenal hyperplasia (IAH). Blood samples were taken hourly during 24 hours at the time of the diagnosis and three months later, a...

In this study we wanted to assess whether affective changes influence cortisol response during low dose (1 microgram) ACTH test. Beck Inventory of Depression and Hamilton Anxiety Rating Scale and low dose ACTH test were performed in five subjects during the prolonged psychological stress induced by war and 18 months later. After the war, Beck Inventory of Depression and Hamilton Anxiety Rating Scale scores were significantly reduced. Suppression of the HPA axis was present dur...